Platinum(IV) combo prodrugs containing cyclohexane-1<i>R</i>,2<i>R</i>-diamine, valproic acid, and perillic acid as a multiaction chemotherapeutic platform for colon cancer
نویسندگان
چکیده
The complex [PtCl 2 (cyclohexane-1 R ,2 -diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA , and potential antimetastatic...
منابع مشابه
VALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
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ژورنال
عنوان ژورنال: Dalton Transactions
سال: 2023
ISSN: ['1477-9234', '1477-9226']
DOI: https://doi.org/10.1039/d3dt01876h